by Dept. of Health and Human Services, Public Health Service, National Institutes of Health in Bethesda, Md .
Written in English
|Statement||Carcinogenesis Testing Program, National Cancer Institute, National Institutes of Health, and National Toxicology Program.|
|Series||Carcinogenesis technical report series ; no. 199, DHHS publication ; no. (NIH) 80-1755, NTP ; 80-19, DHHS publication -- no. (NIH) 80-1755., NTP (Series) -- 80-19.|
|Contributions||National Institutes of Health (U.S.).|
|The Physical Object|
|Pagination||viii, 63 p. :|
|Number of Pages||63|
Carcinogenicity Selenium sulfide is reasonably anticipated to be a human carcino-gen based on sufficient evidence of carcinogenicity from studies in experimental animals. Cancer Studies in Experimental Animals Oral exposure to selenium sulfide caused tumors in two rodent spe-cies and at two different tissue sites. Administration of selenium sul-File Size: KB. Long-term animal bioassays for carcinogenicity are used regularly to determine whether chemical agents are capable of inducing cancer in exposed animals. Two important aspects of current bioassays are that testing covers a substantial portion . A bioassay is an analytical method to determine concentration or potency of a substance by its effect on living cells or tissues. Bioassays are quantitative biological assays used to estimate the potency of agents by observing their effects on living animals (in vivo) or tissue/cell culture systems (in vitro).. A bioassay experiment can either be qualitative or quantitative, direct or . Bioassay of sulfallate for possible carcinogenicity (CAS No. ). National Toxicology Program. A bioassay for possible carcinogenicity of sulfallate was conducted using Osborne-Mendel rats and B6C3F1 mice. Sulfallate was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species.
Regulatory agencies currently rely on rodent carcinogenicity bioassay data to predict whether or not a given chemical poses a carcinogenic threat to humans. We argue that it is always more useful to know a chemical's carcinogenic potency (with confidence limits) than to be able to say only qualitatively that it has been found to be a by: The book will be a valuable source of information to students in the experimental area of statistical aspects of biological assay, professional statisticians with an interest in research in this topic, teachers in statistics and biology, and investigators in the biological and medical sciences who use bioassay in their by: Bioassay definition is - determination of the relative strength of a substance (such as a drug) by comparing its effect on a test organism with that of a standard preparation. Both are procedures by which the potency or the nature of a substance is estimated by studying its effects on living matter. Bioassay is a procedure for the determination of the concentration of a particular constitution of a mixture . Structure of Biological Assay. The typical bioassay involves a stimulus applied to a subject.
Environmental Inquiry is a website and curriculum series developed at Cornell University to help students conduct environmental science research and participate in . bioassay: [ bi″o-as´a ] determination of the active power of a drug sample by comparing its effects on a live animal or an isolated organ preparation with those of a reference standard. Animal Carcinogenicity Studies: 3. Alternatives to the Bioassay. carcinogenicity bioassay in the general literature and the potential for the possible incorporation of alternative tests. Bioassay of Selsun for possible carcinogenicity [print]  National Cancer Institute (U.S.). [Bethesda, Md.]: Dept. of Health and Human Services, Public Health Service, National Institutes of Health, Aug.